With approximately $2 billion in facility-specific investment and more than 500 permanent operating jobs announced, this project clears both of AFT's qualifying thresholds ($100 million in facility-specific investment OR 100 permanent operating jobs). It is also confirmed by official public sources and involves a physical manufacturing facility in the United States.
View full methodology →The pharmaceuticals context.
Pharmaceutical manufacturers are committing billions to new U.S. production capacity for active ingredients, injectable medicines, biologics and other high-demand treatments. North Carolina and Indiana remain major centers of investment, while new facilities are being planned across the South. The current project pipeline includes both large greenfield campuses and major expansions of established production sites.
At a glance
- Company
- Roche Group (Genentech)
- Industry
- Pharmaceuticals
- Location
- Holly Springs, North Carolina
- Investment
- Approximately $2.00B
- Permanent jobs announced
- More than 500
- Status
- Under Construction
- Announced
- May 12, 2025
- Expected opening
- 2029
- Added to tracker
- Sep 1, 2026
Official references
- Genentech's January 20, 2026 superseding $2 billion Holly Springs manufacturing-investment announcement https://www.gene.com/media/press-releases/15096/2026-01-20/genentech-more-than-doubles-investment-i
- Genentech and Roche's May 12, 2025 initial Holly Springs manufacturing announcement https://www.gene.com/media/press-releases/15059/2025-05-12/roche-and-genentech-announce-new-north-c
- Genentech and Roche's August 25, 2025 Holly Springs groundbreaking announcement https://www.roche.com/media/releases/med-cor-2025-08-25
- Genentech's August 18, 2026 Holly Springs topping-out update https://www.gene.com/media/press-releases/15122/2026-08-18/genentech-marks-topping-out-milestone-fo
Cite this project
American Factory Tracker. "Holly Springs Metabolic-Medicines Biomanufacturing Facility — Roche Group, Holly Springs, NC." https://americanfactorytracker.com/projects/roche-genentech-holly-springs-metabolic-medicines. Accessed November 4, 2026.
Please also cite the original sources listed above for underlying figures.