PharmaceuticalsHouston, TexasAnnounced Sep 23, 2025

Eli Lilly

Next-generation active pharmaceutical ingredient (API) facility at Generation Park in Houston, Texas, for small-molecule medicines including orforglipron. Announced September 23, 2025; expected to create 615 permanent manufacturing jobs and about 4,000 construction jobs. Second of four new U.S. manufacturing sites announced by Lilly in 2025. Expected to be operational within five years.

Investment
$6.50B
Permanent jobs announced
615
Status
Planning
Expected opening
Jan 1, 2030
Why it matters

The pharmaceuticals context.

Pharmaceutical manufacturers are committing billions to new U.S. production capacity for active ingredients, injectable medicines, biologics and other high-demand treatments. North Carolina and Indiana remain major centers of investment, while new facilities are being planned across the South. The current project pipeline includes both large greenfield campuses and major expansions of established production sites.

Project record

At a glance

Company
Eli Lilly
Industry
Pharmaceuticals
Location
Houston, Texas
Investment
$6.50B
Permanent jobs announced
615
Status
Planning
Announced
Sep 23, 2025
Expected opening
Jan 1, 2030
Added to tracker
Feb 10, 2026
Sources

Official references

  • Primary source
    https://investor.lilly.com/news-releases/news-release-details/lilly-plans-build-new-65-billion-facility-manufacture-active
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