Holly Springs Drug-Substance Biomanufacturing Facility (Initial Phase)

Amgen's drug-substance biologics manufacturing facility in Holly Springs, North Carolina. Announced August 3, 2021 at $550M with 355 full-time jobs; groundbreaking held March 8, 2022 (see amgen.com/stories/2022/03), ribbon-cutting January 2025. The separately announced December 2024 $1B Holly Springs expansion and Amgen's above-$1.5B / above-700-job site rollup are excluded from this record to prevent double counting.

Investment
$550.0M
Permanent jobs announced
355
Status
Operational
Operations began
Jan 1, 2025
Why this project qualifies

With $550 million in facility-specific investment and 355 permanent operating jobs announced, this project clears both of AFT's qualifying thresholds ($100 million in facility-specific investment OR 100 permanent operating jobs). This project also meets AFT's primary-source verification and physical U.S. manufacturing-footprint requirements.

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Why it matters

The pharmaceuticals context.

Pharmaceutical manufacturers are committing billions to new U.S. production capacity for active ingredients, injectable medicines, biologics and other high-demand treatments. North Carolina and Indiana remain major centers of investment, while new facilities are being planned across the South. The current project pipeline includes both large greenfield campuses and major expansions of established production sites.

Project record

At a glance

Company
Amgen (Holly Springs)
Industry
Pharmaceuticals
Location
Holly Springs, North Carolina
Investment
$550.0M
Permanent jobs announced
355
Status
Operational
Announced
Aug 3, 2021
Operations began
Jan 1, 2025
Added to tracker
Feb 25, 2026
Sources

Official references

Related

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