Holly Springs Drug-Substance Manufacturing Expansion (2024 Phase)

$1B expansion of the Holly Springs, North Carolina drug-substance manufacturing site announced December 5, 2024. Adds 370 additional full-time jobs on top of the original $550M / 355 jobs; brings total planned site investment above $1.5B and total site employment above 700 by 2032. Separately tracked from the 2021 initial facility; that initial $550M / 355 jobs and the above-$1.5B site rollup are explicitly excluded from these figures.

Investment
$1.00B
Permanent jobs announced
370
Status
Under Construction
Expected opening
Jan 1, 2027
Why this project qualifies

With $1 billion in facility-specific investment and 370 permanent operating jobs announced, this project clears both of AFT's qualifying thresholds ($100 million in facility-specific investment OR 100 permanent operating jobs). This project also meets AFT's primary-source verification and physical U.S. manufacturing-footprint requirements.

View full methodology →
Why it matters

The pharmaceuticals context.

Pharmaceutical manufacturers are committing billions to new U.S. production capacity for active ingredients, injectable medicines, biologics and other high-demand treatments. North Carolina and Indiana remain major centers of investment, while new facilities are being planned across the South. The current project pipeline includes both large greenfield campuses and major expansions of established production sites.

Project record

At a glance

Company
Amgen (Holly Springs Expansion)
Industry
Pharmaceuticals
Location
Holly Springs, North Carolina
Investment
$1.00B
Permanent jobs announced
370
Status
Under Construction
Announced
Dec 5, 2024
Expected opening
Jan 1, 2027
Added to tracker
Feb 25, 2026
Sources

Official references

Related

Other projects to know

Back to the tracker/projects/amgen-holly-springs-expansion-holly-springs